The Interaction of Secretin and Pancreozymin on the External Pancreatic Secretion in Dogs

Abstract

Abstract The pancreatic secretion of fluid, bicarbonate and protein in 4 dogs with chronic Thomas type fistulae, has been studied in response to secretin (1U/kg b.w.), pancreozymin (1U/kg b.w.) and combined secretin‐pancreozymin (1U/kg b.w. of each). The secretion rates of fluid, bicarbonate and protein after combined, submaximal stimulation were highly reproducible, as indicated by the coefficients of variation 1.7 per cent (fluid), 3.9 per cent (bicarbonate) and 5.1 per cent (protein). The secretion rates of fluid and bicarbonate obtained after the combined stimulation with secretin‐pancreozymin (1U/kg b.w. of each) were very close to those obtained after isolated stimulation with maximal doses of secretin. Secretin and pancreozymin are shown to have a potentiating effect on the pancreatic secretion of bicarbonate, but only an additive effect on the secretion of protein.