Neoadjuvant bevacizumab persistently inactivates VEGF at the time of surgery despite preoperative cessation

Abstract

These data document that following a cessation time of 6 weeks, bevacizumab is fully active and blocks circulating and local VEGF at the time of liver resection. However, despite effective VEGF inactivation no increase in perioperative morbidity is recorded suggesting that VEGF activity is not essential in the immediate postoperative recovery period.