Concepedia

Design of a Novel Inherently Chiral Calix[4]arene for Chiral Molecular Recognition

Seiji Shirakawa, Akihiro Moriyama, Shoichi Shimizu

Organic Letters · 2007 · 109 citations · 11 references

DOI

Concepts

Abstract

A newly designed inherently chiral calix[4]arene was synthesized and resolved to an optically pure form. Enantiomeric recognition ability of the chiral calix[4]arene was examined using 1H NMR experiments with mandelic acid. In addition, the chiral calix[4]arene was applied to asymmetric reactions, as an organocatalyst.

References

11

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Inherently chiral calixarenes

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Chiral Recognition of α‐Amino Acid Derivatives with a Homooxacalix[3]arene: Construction of a Pseudo‐<i>C</i><sub>2</sub>‐Symmetrical Compound from a <i>C</i><sub>3</sub>‐Symmetrical Macrocycle

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