CD8+ T-Cell Depletion and Rapamycin Synergize with Combined Coreceptor/Stimulation Blockade to Induce Robust Limb Allograft Tolerance in Mice

Asialo GM1+ CD8+ T cells play a critical role in costimulation blockade–resistant allograft rejection

Joel Trambley, Adam W. Bingaman, Angello Lin et al. · Journal of Clinical Investigation · 1999 · 352 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Contrasting Effects of Cyclosporine and Rapamycin in De Novo Generation of Alloantigen-Specific Regulatory T Cells

Wenda Gao, Yan Lu, Basset El Essawy et al. · American Journal of Transplantation · 2007 · 257 citations · Full text

Life Sciences, Cell Biology, Immunology +17

SIROLIMUS (RAPAMYCIN) FOR THE TREATMENT OF STEROID-REFRACTORY ACUTE GRAFT-VERSUS-HOST DISEASE1

Ana Benito, Terry Furlong, Paul J. Martin et al. · Transplantation · 2001 · 182 citations

Life Sciences, Immunology, Pharmacotherapy +11

The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade

Peter Blaha, Sinda Bigenzahn, Zvonimir Koporc et al. · Blood · 2003 · 175 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Allograft Rejection by Primed/Memory CD8+ T Cells Is CD154 Blockade Resistant: Therapeutic Implications for Sensitized Transplant Recipients

Yuan Zhai, Lingzhong Meng, Feng Gao et al. · The Journal of Immunology · 2002 · 167 citations · Full text

Life Sciences, Immunology, Cardiac Transplantation +15