DHPLC-based germline mutation screening in the analysis of the VHL tumor suppressor gene: usefulness and limitations

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms.

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa et al. · Proceedings of the National Academy of Sciences · 1989 · 3.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

Farida Latif, Kálmán Tory, James R. Gnarra et al. · Science · 1993 · 3K citations

Medicine, Genetics, Molecular Genetics +17

Mutations of the VHL tumour suppressor gene in renal carcinoma

James R. Gnarra, Kálmán Tory, Y Weng et al. · Nature Genetics · 1994 · 1.7K citations

Medicine, Genetics, Molecular Genetics +14

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

James G. Herman, Farida Latif, Y Weng et al. · Proceedings of the National Academy of Sciences · 1994 · 1.5K citations

Medicine, Genetics, Oncology +17

Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan

Berton Zbar, Takeshi Kishida, Fan Chen et al. · Human Mutation · 1996 · 504 citations

Medicine, Genetics, Molecular Genetics +17