The Journal of Antibiotics · 1999 · 26 citations · 3 references
PharmacyPharmaceutical BiotechnologyDrug DiscoveryAntibiotic ResistanceAntibiotic DiscoveryMarine Polyketide BiosynthesisMarine PolyketidesMicrobial Production Of PolyketidesPolyketide Antibiotics
Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.
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13C nmr study of α- and β-anomeric pairs of d-mannopyranosides and l-rhamnopyranosides
R. Kasai, Miho Okihara, J. Asakawa et al. · Tetrahedron · 1979 · 401 citations