FEBS Letters · 1992 · 29 citations · 10 references
Life SciencesImmunologyInfectious DiseasesMolecular VirologyReproductive ImmunologyVirologyMother-to-child Transmission PreventionPlacental DevelopmentPlacental ImmunologyPlacental PhysiologyPregnancy ImmunologyHiv InfectiousnessInhibitory TransmissionIntrauterine EnvironmentMother-to-child Hiv TransmissionPerinatal Hiv PreventionTrophoblast-immune Cell InteractionsViral Replication Control
It has been demonstrated that human chorionic gonadotropin (hCG) inhibits HIV production in vitro, suggesting that this soluble placental glycoprotein can control viral replication and spread in vivo. hCG--the major product of fetal trophoblasts--was tested on an in vitro model consisting of choriocarcinoma-derived ENAMI trophoblasts exposed to HIV-infected MOLT-4 lymphocytes. The results show a U-shaped antiviral dose-effect and suggest that hCG may contribute to protection against intrauterine transmission of HIV-1.
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D Harbour-McMenamin, Eric M. Smith, J. Edwin Blalock · Proceedings of the National Academy of Sciences · 1986 · 60 citations