Concepedia

RECIOSELECTIVE ALKYL GROUP INTRODUCTION AT THE 3-POSITION OF PYRIDINE VIA 1,4-BIS(TRIMETHYLSILYL)-1,4-DIHYDROPYRIDINE

Otohiko Tsuge, Shuji Kanemasa, Toshio Naritomi, Junji Tanaka

Chemistry Letters · 1984 · 29 citations · 16 references

DOI

Concepts

Abstract

Abstract The reaction of 1,4-bis(trimethylsilyl)-1,4-dihydropyridine with aldehydes and ketones in the presence of tetrabutylammonium fluoride offers a convenient method for the preparation of 3-alkylpyridines.

References

16

Regioselective ortho lithiation of halopyridines

Gordon W. Gribble, Mark G. Saulnier · Tetrahedron Letters · 1980 · 143 citations

, , +5

Reaction of Cuprate Reagents with Pyridine in the Presence of Chloroformate. A Novel Synthesis of 1,4-Dihydropyridine Derivatives

Edward Piers, Marcel Soucy · Canadian Journal of Chemistry · 1974 · 80 citations

, , +7

Regioselective synthesis of 4-alkylpyridines via 1,4-dihydropyridine derivatives from pyridine

Kin‐ya Akiba, Yuji Iseki, Makoto Wada · Tetrahedron Letters · 1982 · 79 citations

, , +8

Substitutions of pyridines activated by oxazolines via nucleophilic additions for metalation-alkylation

A. I. MEYERS, Richard A. Gabel · The Journal of Organic Chemistry · 1982 · 63 citations

, , +8

Regioselective synthesis of 4-(2-oxoalkyl)pyridines via 1,4-dihydro-pyridine derivatives using silyl enol ethers and pyridinium salts

Kin‐ya Akiba, Yoshihiro Nishihara, Makoto Wada · Tetrahedron Letters · 1983 · 63 citations

, , +9