Flavonoids inhibit the platelet TxA₂signalling pathway and antagonize TxA₂receptors (TP) in platelets and smooth muscle cells

Abstract

These data further suggest that flavonoids may inhibit platelet function by binding to TP and by subsequent abrogation of downstream signalling. Binding of these compounds to TP occurs in human myometrium and in TP-transfected HEK 293T cells and suggests that antagonism of TP might mediate the effects of flavonoids in different tissues.