Ophthalmologica · 2000 · 22 citations · 10 references
Life SciencesOphthalmologyAgingNeurodegenerationOcular DiseaseAge-related Macular DegenerationAntioxidant DefenseMacular DegenerationMacular DiseaseOxidative StressReactive Oxygen SpeciesAge-related Macular Degeneration BiomarkersAge-related Oxidative StressBiochemical Stress MarkersFree Radical OxidationLipid Peroxidation MarkersOxidative Damage BiomarkersOxidative Stress Injury
To seek some specific biochemical markers of age-related macular degeneration (AMD), coenzyme Q10 (CoQ10) levels were determined in plasma and platelets from 19 exudative AMD patients and 19 age-matched controls. Lipid peroxidation was followed in plasma in vitro after the addition of a free radical initiator. Most patients had lower plasma CoQ10 content than most controls. Plasma from controls showed greater capacity to oppose the oxidative damage. These results support the concept that free radicals play a pathogenic role in AMD and that CoQ10 may have a protective effect.
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The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity.
Ronald Klein, Qin Wang, Scot E. Moss et al. · PubMed · 1995 · 464 citations