Functional implications of short‐term retinal detachment in porcine eyes: study by multifocal electroretinography

Abstract

Access to the subretinal space in pigs can be gained without permanent detectable changes in the mfERG. A short-term retinal detachment was found to cause only reversible electrophysiological and histological changes in the outer retina, which suggests that this procedure is tolerated well in the porcine retina. The size of the known destructive lesion (retinotomy) was too small to be detected, given the spatial resolution of the mfERG method applied. In the future, the presented protocol can be used to assess the functional outcome of surgery and transplantation in the subretinal space in pigs.