Sensors · 2010 · 114 citations · 44 references
MedicineNuclear MedicineRadiologyBiomedical ImagingDiagnostic ImagingMolecular ImagingDetector TechnologyPhotodetectorsPositron Emission TomographyPositron Emission Tomography PhysicsRadiation Imaging DetectorsScintillation DetectorsDetector DesignPhotomultiplier DetectorsPhotomultiplier TubesScintillationSilicon PhotomultipliersTime ResolutionTime-of-flight PetTime-of-flight Positron Emission Tomography
We present the most recent advances in photo-detector design employed in time of flight positron emission tomography (ToF-PET). PET is a molecular imaging modality that collects pairs of coincident (temporally correlated) annihilation photons emitted from the patient body. The annihilation photon detector typically comprises a scintillation crystal coupled to a fast photo-detector. ToF information provides better localization of the annihilation event along the line formed by each detector pair, resulting in an overall improvement in signal to noise ratio (SNR) of the reconstructed image. Apart from the demand for high luminosity and fast decay time of the scintillation crystal, proper design and selection of the photo-detector and methods for arrival time pick-off are a prerequisite for achieving excellent time resolution required for ToF-PET. We review the two types of photo-detectors used in ToF-PET: photomultiplier tubes (PMTs) and silicon photo-multipliers (SiPMs) with a special focus on SiPMs.
44
Avalanche photodiodes and quenching circuits for single-photon detection
S. Cova, Massimo Ghioni, Andrea L. Lacaita et al. · Applied Optics · 1996 · 1.1K citations
High-energy-resolution scintillator: Ce3+ activated LaBr3
Edgar van Loef, P. Dorenbos, C.W.E. van Eijk et al. · Applied Physics Letters · 2001 · 655 citations
Benefit of Time-of-Flight in PET: Experimental and Clinical Results
Joel S. Karp, Suleman Surti, Margaret E. Daube-Witherspoon et al. · Journal of Nuclear Medicine · 2008 · 584 citations · Full text