Journal of the American Chemical Society · 2005 · 143 citations · 6 references
PharmacyBiologyChemistryCombinatorial ChemistryDrug DiscoverySignal TransductionChemical Library DesignChemical Probe DiscoveryLigand BindingMolecular SensorsReceptor-ligand InteractionsSmall-molecule ScreeningCombinatorial SearchFluorescence ProbesFluorescent Chemical ProbesFluorescent Molecular SensorsFluorescent SensingFluorophore ChemistryFluorophore DesignOrganic Fluorophores
We report here a new approach to the discovery of fluorescent chemosensors in which a new signaling mechanism allows a core fluorophore to be used in a combinatorial search for new binding events, thus reversing the reigning discovery paradigm.
6