Regulation of pre–B cell colony‐enhancing factor by STAT‐3–dependent interleukin‐6 <i>trans</i>‐signaling: Implications in the pathogenesis of rheumatoid arthritis

Abstract

Experiments presented herein demonstrate that PBEF is regulated via IL-6 trans-signaling and the IL-6-related cytokine OSM. PBEF is also actively expressed during arthritis. Although these data confirm an involvement of PBEF in disease progression, the consequence of its action remains to be determined.