Insight into metabolism of CHO cells at low glucose concentration on the basis of the determination of intracellular metabolites

Methods of Enzymatic Analysis

Journal of AOAC INTERNATIONAL · 1975 · 19.9K citations

Life Sciences, Biochemistry, Analytical Chemistry +11

Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.

Larry Reitzer, Burton M. Wice, David Kennell · Journal of Biological Chemistry · 1979 · 1.2K citations · Full text

Life Sciences, Biochemistry, Cell Biology +10

Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblasts

H. Ronald Zielke, Pinar T. Ozand, J. Tyson Tildón et al. · Journal of Cellular Physiology · 1978 · 273 citations

Life Sciences, Biochemistry, Cell Biology +9

Multiple steady states with distinct cellular metabolism in continuous culture of mammalian cells

Anna Europa, Anshu Gambhir, Pengcheng Fu et al. · Biotechnology and Bioengineering · 2000 · 178 citations

Life Sciences, Biochemistry, Bioenergetics +13

High viable cell concentration fed‐batch cultures of hybridoma cells through on‐line nutrient feeding

Weichang Zhou, Jutta Rehm, Wei‐Shou Hu · Biotechnology and Bioengineering · 1995 · 167 citations

Life Sciences, Biotechnology, Cell Biology +17