Use of Sodium Fluorescein Solution for Detection of Cerebrospinal Fluid Fistulas: An Analysis of 420 Administrations and Reported Complications in Europe and the United States

Abstract

Complications from intrathecal application of fluorescein appears to be dose dependent. At concentrations of 5%, or preferably lower, side effects are transient. A grand mal seizure can be minimized when following the general cautions of lumbar puncture and dose. The patient should be supervised for 24 hours. A written informed consent from patients for use of fluorescein is recommended.