Successful Treatment of Dry Eye in Two Patients With Chronic Graft-versus-host Disease With Systemic Administration of FK506 and Corticosteroids

Abstract

Systemic administration of FK506 with corticosteroids is an effective treatment of severe dry eye in patients with CGVHD, but long-term administration may be required to achieve a lasting response. These cases also suggest that further investigation into the use of topical FK506 and prednisolone as a maintenance therapy should be pursued.