Antiarthritic activity of an orally active C5a receptor antagonist against antigen‐induced monarticular arthritis in the rat

Abstract

An agent that inhibits the action of C5a in this model significantly reduced joint pathology, while ibuprofen was not effective. C5a antagonists could therefore have broader therapeutic benefits than nonsteroidal antiinflammatory drugs as antiarthritic agents for rheumatoid arthritis.