Therapeutic Drug Monitoring · 2006 · 24 citations · 4 references
PharmacyPharmacologyToxicologyAnalytical ToxicologyPsychopharmacologySubstance Use DisordersAnticholinergic ToxicityClinical Manifestations Of IntoxicationStimulant ToxicologySubstance IntoxicationToxicological Drug ScreeningToxidrome RecognitionAnticholinergic DrugsAnticholinergic Poisoning DiagnosisAnticholinergic ToxidromeClinical Features Of IntoxicationCocaine ToxicityIllicit Drug DetectionSerum BiomarkersToxicologic Diagnosis
An unexpectedly high number of initially suspected cocaine-intoxicated patients was presented to a general hospital in Lelystad, The Netherlands. Based on the unusual toxidram rate of not fitting cocaine intoxication, the suspicion of co-presence of an anticholinergic agent was raised. A newly developed HPLC-MS/MS analytical method revealed the presence of 10% atropine in a cocaine sample retrieved and subsequently in the sera of 6 intoxicated patients.
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Pharmacokinetic Studies on Atropine with Special Reference to Age
R Virtanen, J Kanto, E Iisalo et al. · Acta Anaesthesiologica Scandinavica · 1982 · 64 citations