Dual chiral recognition system involving cyclodextrin derivatives in capillary electrophoresis

Abstract

Abstract An immobilized chiral stationary phase, Chirasil‐Dex, coated onto the inner surface of a 50 μm i.d. capillary and cyclodextrin derivatives added to the running buffer were simultaneously used for the study of enantiomer separations by capillary electrophoresis. Dependent on the cyclodextrin concentration in the mobile phase, a reversal of the elution order of enantiomers due to dual chiral recognition mechanisms was observed.