Electron-Transfer Properties of Active Aldehydes of Thiamin Coenzyme Models, and Mechanism of Formation of the Reactive Intermediates

Abstract

Highly efficient electron transfer from an active aldehyde (2−) to [CoII(phen)3]2+ (phen=1,10-phenanthroline) occurs following the rate-determining formation of active aldehydes from 3-benzylthiazolium salts (1+) and aldehydes in the presence of DBU to give the corresponding radical intermediates (2\.), which have been characterized by ESR.