Angewandte Chemie International Edition · 2003 · 42 citations · 29 references
PharmacyMedicinal ChemistryPharmacologySynthetic Medicinal ChemistryMarine Drug DiscoveryMarine Natural ProductsNatural Product Drug DiscoveryBioactive Marine Metabolites
The marine sponge metabolites phorboxazoles A (see structural formula) and B were the targets of several clever total syntheses, whose special features are described in this Highlight. Now that the synthetic entry to these compounds has been cleared, their cytostatic activity can be studied thoroughly in vitro and in vivo.
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David A. Evans, Marisa C. Kozlowski, Jerry A. Murry et al. · Journal of the American Chemical Society · 1999 · 388 citations