A PROPOSED MECHANISM FOR THE ACTION OF 9-β-<scp>D</scp>-ARABINO-FURANOSYLADENINE AS AN INHIBITOR OF THE GROWTH OF SOME ASCITES CELLS

Abstract

The effect of 9-β-D-arabinofuranosyladenine triphosphate on the incorporation of thymidine monophosphate- 14 C into DNA by cell-free extracts of TA3 ascites tumor cells has been studied. Arabinosyl adenine triphosphate is a non-competitive inhibitor of DNA polymerase in TA3 cells. The K i is 9 × 10 −5 M. This effect reasonably accounts for the ability of the compound to inhibit the growth of several ascites tumors in mice.