Concepedia

Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor

Orsolya Galamb, Sándor Spisák, Ferenc Sípos, Kinga Tóth, Norbert Solymosi, Barnabás Wichmann, Tibor Krenács, Gábor Valcz, Zsolt Tulassay, Béla Molnár

British Journal of Cancer · 2010 · 85 citations · 34 references

DOIFull text

Open access

Abstract

NS398 has a reversal effect on the expression of several genes that altered in colorectal adenoma-carcinoma sequence. NS398 more efficiently inverted the expression changes seen in the normal-adenoma than in the normal-carcinoma transition.

References

34

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen · Methods · 2001 · 176.9K citations

, , +12

Diagnosis of multiple cancer types by shrunken centroids of gene expression

Robert Tibshirani, Trevor Hastie, Balasubramanian Narasimhan et al. · Proceedings of the National Academy of Sciences · 2002 · 2.9K citations · Full text

, , +22

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

Charles E. Eberhart, R J Coffey, Radhika Aramandla et al. · Gastroenterology · 1994 · 2.5K citations · Full text

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

Gideon Steinbach, Patrick M. Lynch, Robin Phillips et al. · New England Journal of Medicine · 2000 · 2.5K citations · Full text

Celecoxib for the Prevention of Sporadic Colorectal Adenomas

Monica M. Bertagnolli, Craig Eagle, Ann G. Zauber et al. · New England Journal of Medicine · 2006 · 1K citations · Full text