Biochemistry · 1984 · 41 citations · 36 references
Life SciencesBiochemistryCell BiologyBiophotonicsCytoskeletonMolecular BiophysicsCytoskeletal ArchitectureCytoskeletal AssemblyCytoskeletal Associated ProteinsMicrotubule Assembly InhibitionMicrotubule-associated ProteinsUltraviolet Radiation BiologyInhibition Of Tubulin AssemblyMicrotubule Assembly DisruptionMicrotubule PolymerizationMicrotubule Polymerization DisruptionMicrotubule Polymerization InhibitionTubulin Polymerization InhibitorsUltraviolet Light ExposureUltraviolet Light Treatment
Exposure of microtubular protein to ultraviolet light inhibits its assembly into morphologically normal microtubules. This effect appeared to result primarily from damage to the tubulin dimers. The damage consisted of a conformational change, a loss of two free sulfhydryl groups, a production of higher molecular weight cross-linked species, and the formation of aggregated amorphous material upon polymerization.
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