Interleukin‐8 secretion in patients with allergic rhinitis after an allergen challenge: interleukin‐8 is not the main chemotactic factor present in nasal lavages

Abstract

These data show that allergen challenge increased significantly the secretion of IL-8 for the patients with allergic rhinitis. However, neutralization of IL-8 in nasal lavages by a specific antibody revealed that the role of this chemokine in granulocyte infiltrate was limited, suggesting that IL-8 acts in connection with other chemotactic factors in this recruitment.