Pregnancy‐Specific Glycoproteins Function as Immunomodulators by Inducing Secretion of IL‐10, IL‐6 and TGF‐β1 by Human Monocytes - Concepedia

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Pregnancy‐Specific Glycoproteins Function as Immunomodulators by Inducing Secretion of IL‐10, IL‐6 and TGF‐β1 by Human Monocytes

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References

2001

Year

Sara Snyder, Jennifer Wessells, Roseann Waterhouse, Gabriela Dveksler, DAVID H. WESSNER, Larry M. Wahl, Wolfgang Zimmermann

American Journal of Reproductive Immunology

Abstract

PSG1, PSG6, PSG6N, and PSG11 induce dose-dependent secretion of anti-inflammatory cytokines by human monocytes. Human and murine PSGs exhibit cross-species activity. Our results are consistent with a role for PSGs in modulation of the innate immune system.