Journal of Clinical Gastroenterology · 1993 · 45 citations · 0 references
MedicinePharmacotherapyGastroenterologyGastrointestinal PharmacotherapyInflammationAnti-inflammatory PharmacologyColonic DisordersGastrointestinal InflammationInflammatory Bowel DiseaseIntestinal IschemiaNonopioid AnalgesicsColonic InflammationDrug-induced ColitisEtiologic HypothesisInflammatory Bowel Disease PathophysiologyNonsteroidal Anti-inflammatory Drug GastropathyNonsteroidal Anti-inflammatory Drug ManagementNonsteroidal Anti-inflammatory Drug PharmacologyNsaid Therapy
We have seen two cases of a segmental ischemic colitis develop during nonsteroidal antiinflammatory drug (NSAID) treatment. No other possible etiologic factors were shown. The short-term clinical course and the follow-up were uneventful. NSAIDs have been reported to cause different lesions in the large bowel, either by worsening preexisting colonic diseases or by inducing a primary pathology. We suggest that ischemia should be considered a possible mechanism of NSAID-associated colitis. Such ischemic colitis, not triggered by severe cardiovascular disease or operation, may be related to NSAIDs more often than currently recognized.