Deletion of the long arms of chromosome 18 (46,XX,18q-) associated with absence of IgA and hypothyroidism in an adult.

Abstract

London et al (1964) recorded the case of a 28-yearold woman who had menstrual periods for 5 years and then became amenorrhoeic. He assumed thai the XX cells had to be present for the ovaries tc function regularly as indicated by normal menstruation. If there is a lack of these XX cells primary amenorrhoea will occur and if the XX cells arc 'used up' then the amenorrhoea will be secondary.