Rhodium-Catalyzed Enantioselective Addition of Boronic Acids to <i>N</i>-Benzylnicotinate Salts

Abstract

The highly enantioselective catalytic asymmetric addition of aryl and alkenylboronic acids to N-benzylnicotinate salt 1 is described. The dihydropyridine 2 reaction products can be converted to synthetically useful piperidines. Application of the methodology to the preparation of enantioenriched quaternary chiral centers is also discussed.