Functional Analysis of the Role of the<i>TPMT</i>Gene Promoter VNTR Polymorphism in<i>TPMT</i>Gene Transcription

Abstract

Overall, our data underline that both the number and type of VNTRs, as well as the upstream regulatory region of the TPMT gene promoter, determine the overall level of TPMT gene transcription. It remains to be seen whether these VNTRs can be employed as pharmacogenetic markers to individualize thiopurine therapy.