Congenital Combined Deficiency of Coagulation Factors II, VII, IX and X

Abstract

PLASMA activities of coagulation factors II (prothrombin), VII (proconvertin), IX (Christmas factor) and X (Stuart factor) have in common 3 generally recognized characteristics: these activities are depressed to a mutual degree in vitamin K deficiency acquired by impaired gastrointestinal absorption or coumarin therapy and also in hepatic dysfunction; they are presumably derived from undefined functions of vitamin K and functionally intact hepatic cells; and they are preferentially adsorbed onto barium sulfate and certain related compounds. In view of the clinical and biochemical relation of these 4 coagulation factors, the term "prothrombin complex" has been applied to them.1 Isolated deficiency of . . .