Propranolol in the Treatment and Prevention of Cardiac Arrhythmias

Abstract

Article1 April 1967Propranolol in the Treatment and Prevention of Cardiac ArrhythmiasRALPH GIANELLY, M.D., JOHN R. GRIFFIN, M.D., DONALD C. HARRISON, M.D.RALPH GIANELLY, M.D., JOHN R. GRIFFIN, M.D., DONALD C. HARRISON, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-4-667 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe sympathetic nervous system exerts an important influence on the regulation of heart rate. The ventricular rate may be increased either by stimulating the cardiac sympathetic nerves (1) or by administering catecholamines (2). This excitatory influence on the heart rate is generally considered to be mediated by the beta-adrenergic neuroreceptors of Ahlquist's classification (3). Blockade of the beta-adrenergic system would therefore be expected to alter the heart rate and consequently to have an effect in patients with a variety of cardiac arrhythmias. Although dichloroisoproterenol was the first specific beta blocking drug, it was not widely used because of its sympathomimetic...References1. RANDALLMCNALLY WCH: Augmentor action of sympathetic cardiac nerves in man. J. Appl. Physiol. 15: 629, 1960. CrossrefMedlineGoogle Scholar2. ANZOLARUSHMER JRF: Cardiac responses to sympathetic stimulation. Circ. Res. 4: 302, 1956. CrossrefMedlineGoogle Scholar3. AHLQUIST RP: Study of adrenotropic receptors. Amer. J. Physiol. 153: 586, 1948. CrossrefMedlineGoogle Scholar4. DRESEL PE: Blockade of some cardiac actions of adrenaline by dichloroisoproterenol. Canad. J. Biochem. 38: 375, 1960. CrossrefMedlineGoogle Scholar5. MORANPERKINS NCME: Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol. J. Pharmacol. Exp. Ther. 124: 223, 1958. MedlineGoogle Scholar6. BLACKSTEPHENSON JWJS: Pharmacology of new adrenergic beta-receptor-blocking compound (Nethalide). Lancet 2: 311, 1962. CrossrefMedlineGoogle Scholar7. 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J. Pharmacol. 21: 473, 1963. Google Scholar20. SEKIYAVAUGHN WILLIAMS AEM: The effects of pronethalol, dichloroisoprenaline and disopyramide on the toxicity to the heart of ouabain and anesthetics. Ibid., p. 462. Google Scholar21. SLOMANROBINSONMCLEAN GJSK: Propranolol (Inderal) in persistent ventricular fibrillation. Brit. Med. J. 1: 895, 1965. CrossrefMedlineGoogle Scholar22. PAYNESENFIELD JPRM: Pronethalol in treatment of ventricular arrhythmias during anaesthesia. Brit. Med. J. 1: 603, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Palo Alto, CaliforniaFrom the Cardiology Division, Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif.This study was supported by grant HE 090580-03 and training grant 1 T1 HE 5709-01, the National Institutes of Health, Bethesda, Md., and by a grant from the Fresno County Heart Association.Requests for reprints should be addressed to Donald C. Harrison, M.D., Cardiology Division, Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif. 94304 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEvolution and Revolution in Drug Labeling: Regulation of Antiarrhythmic Drugs by the Food and Drug Administration 1962-1996Atrial fibrillation following coronary artery bypass surgeryClass II antiarrhythmic agentsPrevention and Treatment of Supraventricular Tachycardia Shortly After Coronary Artery Bypass Grafting: A Randomized Open TrialArrhythmia prophylaxis after aorta-coronary bypassLong-term therapy of paroxysmal supraventricular tachycardia: A randomized, double-blind comparison of digoxin, propranolol and verapamilPerioperative Beta Blockade with Propranolol: Reduction in Myocardial Oxygen Demands and Incidence of Atrial and Ventricular ArrhythmiasElectrophysiologic actions of high plasma concentrations of propranolol in human subjectsLife-table methods for evaluating antiarrhythmic drug efficacy in patients with paroxysmal atrial tachycardiaManuscript reviewers' commentInfluence of propranolol on supraventricular tachycardia early after coronary artery revascularizationArrhythmia Prophylaxis Using Propranolol after Coronary Artery SurgeryElectrocardiogram Recording By Telephone in Antiarrhythmic Drug TrialsDrugs with a class III antiarrhythmic actionPrevention of supraventricular tachyarrhythmia with low-dose propranolol after coronary bypassAntiarrhythmic effects of acute betablockade with atenolol on supraventricular tachycardias at rest and during exerciseClinical experience with beta adrenergic blocking agents in myocardial ischaemia: A dilemma and a challengeResponse of atrial flutter to overdrive atrial pacing and intravenous disopyramide phosphate, singly and in combination.Propranolol for Prevention of Postoperative Cardiac Arrhythmias: A Randomized StudySuppression of chronic ventricular arrhythmias with propranolol.Refractory arrhythmia in the presence of congestive failure: successful beta sympatholytic treatmentLong-term medical management of hypertrophic obstructive cardiomyopathyBlood Levels of Drugs Used in the Treatment of Cardiac ArrhythmiasElectrophysiology and pharmacology of cardiac arrhythmias. IX. Cardiac electrophysiologic effects of beta adrenergic receptor stimulation and blockade. Part BThe electrophysiology of propranolol in manThe Effects of Propranolol on Induction of A-V Nodal Reentrant Paroxysmal TachycardiaSinus Arrest Induced by Swallowing and PropranololTreatment of Acute Arrhythmias with Orally Administered TolamololCardiac arrhythmias in infants and childrenJunctional TachycardiaUse of alprenolol in acute cardiac arrhythmiasEffect of sotalol on clinical arrhythmiasEffect of β-adrenoceptor blocking agents on poststimulatory atrial flutter in the dog, with observations on the participation of adrenergic mechanisms in this experimental arrhythmiaPrehospital Care of Acute Myocardial InfarctionRecurrent Wolff-Parkinson-White tachycardia in an infantControl of Intractable Ventricular Tachycardia by Coronary RevascularizationRAPID ATRIAL FIBRILLATION SIMULATING VENTRICULAR TACHYCARDIA IN THE WOLFF‐PARKINSON‐WHITE SYNDROMEBeta-blocking agents in cardiac arrhythmiasUse of propranolol in atrial flutterTreatment of recurrent paroxysmal ventricular tachycardiaRapidly Recurring Supraventricular Tachycardiaβ-ReceptorenblockerAntiarrhythmic effectiveness of alprenolol, a new beta adrenergic receptor blocking agentThe use of beta-adrenergic receptor blocking drugs in dysrhythmiasMetabolic response to simultaneous infusion of epinephrine and Propranolol in obese adolescentsConversion of chronic atrial fibrillation to sinus rhythm with combined propranolol and quinidine treatmentDrugs used in the treatment of cardiac arrhythmiasBeta-Adrenergic Receptor Blocking Drugs in the Treatment of Cardiac Arrhythmias 1 April 1967Volume 66, Issue 4Page: 667-676KeywordsArrhythmiaAtrial fibrillationCatecholaminesDrugsHeartHeart rateLongitudinal studiesNervesSympathetic nervous systemTachycardia Issue Published: 1 April 1967 PDF DownloadLoading ...