Asymmetric synthesis of α-amino boronate esters via organocatalytic pinacolboryl addition to tosylaldimines

Abstract

Organocatalytic nucleophilic pinacolboryl addition from in situ generated MeO(-)→ B(2)pin(2) to C=N double bond can be performed enantioselectively with the aid of chiral phosphines, which promote enantiofacial differentiation in the course of the C-B bond formation.