Isoform-Selective Physical Coupling of TRPC3 Channels to IP ₃ Receptors in Smooth Muscle Cells Regulates Arterial Contractility

Abstract

IP(3) stimulates direct coupling between IP(3)R1 and membrane-resident TRPC3 channels in arterial myocytes, leading to I(Cat) activation and vasoconstriction. Close spatial proximity between IP(3)R1 and TRPC3 establishes this isoform-selective functional interaction.