Precore/Core promoter variants to predict significant fibrosis in both <scp>HB</scp>eAg positive and negative chronic hepatitis B

Abstract

We identified strong independent risk factors (age, ALT, HBV-DNA, HBV variants) predicting significant fibrosis (F ≥ 2) independently of HBeAg status in patients with CHB. Patients with BCP variants have a higher risk of severe liver disease. The detection of these mutants may help to predict significant fibrosis (F ≥ 2).