Lack of Activity of Orally Administered Clofazimine against Intracellular<i>Mycobacterium tuberculosis</i>in Whole-Blood Culture

Abstract

The activity of oral clofazimine against intracellular Mycobacterium tuberculosis was compared to that of ofloxacin in healthy volunteers by the use of whole-blood cultures. Clofazimine was inactive whether it was tested alone or combined with other drugs that are used to treat multidrug-resistant tuberculosis, despite a total dose of 2 g. Kanamycin was the most active drug tested.