Antimicrobial Agents and Chemotherapy · 2004 · 21 citations · 15 references
MedicineInfectious DiseasesPharmacologyAntimicrobial PharmacologyClinical PharmacologyMedical MicrobiologyAntibacterial PharmacotherapyPulmonary TuberculosisTuberculosis PharmacotherapyCombination Therapy For TuberculosisMultidrug-resistant OrganismsMultidrug-resistant PathogensMultidrug-resistant Tuberculosis TreatmentMycobacterium Tuberculosis InfectionPhenotypic Drug Susceptibility TestingTuberculosis Drug Resistance
The activity of oral clofazimine against intracellular Mycobacterium tuberculosis was compared to that of ofloxacin in healthy volunteers by the use of whole-blood cultures. Clofazimine was inactive whether it was tested alone or combined with other drugs that are used to treat multidrug-resistant tuberculosis, despite a total dose of 2 g. Kanamycin was the most active drug tested.
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