ABSORPTION AND EXCRETION OF 35S DAPSONE IN DERMATITIS HERPETIFORMIS

Abstract

SUMMARY.– The variability of dosage of dapsone required to control dermatitis herpetiformis is well known but unexplained. As a first step in the investigation of this problem this paper describes the results of estimations of serum levels and urinary excretion levels after a single oral dose of 100 mg. 35S dapsone given to patients with and without dermatitis herpetiformis. For comparison the levels were measured by radio-activity and by chemical methods. Radiochromatographic studies were also carried out to determine the form in which dapsone circulates and is excreted. Autoradiographs of biopsies are also discussed.