A General Framework for Inhibitor Resistance in Protein Kinases

<i>EGFR</i> Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

Susumu Kobayashi, Titus J. Boggon, Tajhal Dayaram et al. · New England Journal of Medicine · 2005 · 3.9K citations · Full text

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Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

William Pao, Vincent A. Miller, Katerina Politi et al. · PLoS Medicine · 2005 · 3.5K citations · Full text

Medicine, Oncology, Pharmacology +17

A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications

Takeharu Nagai, Keiji Ibata, Eun Sun Park et al. · Nature Biotechnology · 2002 · 2.8K citations

Life Sciences, Biochemistry, Cell Biology +16

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

Tatsuya Tamaoki, Hisayo Nomoto, ISAMI TAKAHASHI et al. · Biochemical and Biophysical Research Communications · 1986 · 2.5K citations

Life Sciences, Biochemistry, Pharmacology +10

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

Pharmacy, Medicinal Chemistry, Pharmacology +13