COMPARISON OF THE CONSTANT INFUSION AND URINE COLLECTION TECHNIQUES FOR THE MEASUREMENT OF RENAL FUNCTION 1

Abstract

For any exogenous substance which is neither metabolized, stored nor excreted otherwise than in the urine, the rate of excretion must be equal to the rate of infusion under conditions where its plasma level and volume of distribution are constant. This steady state, as indicated by a constant plasma level, will be designated infusion equilibrium.