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Long‐term results of low‐dose intravenous ciclosporin for acute severe ulcerative colitis

Christopher K. Rayner, G McCormack, Anton Emmanuel, Michael A. Kamm

Alimentary Pharmacology & Therapeutics · 2003 · 49 citations · 20 references

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Abstract

Low-dose intravenous ciclosporin (2 mg/kg/day), usually used as a monotherapy and followed by azathioprine, achieves similar long-term efficacy to higher dose ciclosporin combined with steroids in severe acute ulcerative colitis. Morbidity appears to be low.

References

20

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Kenneth W. Schroeder, William J. Tremaine, Duane M. Ilstrup · New England Journal of Medicine · 1987 · 3K citations

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Simon Lichtiger, D. H. Present, Asher Kornbluth et al. · New England Journal of Medicine · 1994 · 1.7K citations

The course and prognosis of ulcerative colitis: Part I Short-term prognosis

F Edwards, S. C. Truelove · Gut · 1963 · 860 citations · Full text

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Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis1 1Gert Van Assche, Severine Vermeire, Geert D’Haens, and Paul Rutgeerts have been instrumental in the design of the study, trial management, data analysis, and writing the paper. Maja Noman had a major contribution in the clinical ambulatory follow-up of the patients in the trial. Martin Hiele followed cyclosporine levels and adjusted drug doses of patients in the trial and provided statistical advice. Katrien Asnong was the study coordinator and had a major share in data analysis. Joris Arts analyzed safety data and followed patients clinically during the trial. Andre D’Hoore and Freddy Penninckx performed the surgical interventions in patients failing the trial and substantially contributed in evaluating patients for colectomy.

Gert Van Assche, Geert D’Haens, Maja Noman et al. · Gastroenterology · 2003 · 445 citations

Intravenous cyclosporine versus intravenous corticosteroids as single therapy for severe attacks of ulcerative colitis

Geert D’Haens, Liesbeth Lemmens, Frederik Nevens et al. · Gastroenterology · 2001 · 394 citations · Full text

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