Familial vasopressin‐sensitive ACTH‐independent macronodular adrenal hyperplasia (VPs‐AIMAH): clinical studies of three kindreds

Abstract

Adrenal nodules, suppressed ACTH and increased VP sensitivity may represent preclinical disease, allowing early detection, and treatment, of affected individuals. In AIMAH-01, increased VP sensitivity may be due to adrenal VP receptor overexpression. In these kindreds, VPs-AIMAH is familial, and autosomal dominant inheritance is most likely.