Archives of Disease in Childhood · 1971 · 168 citations · 24 references
MedicinePediatricsPhysiologyPediatric PulmonologyPulmonologyVentilationMechanical VentilationPulmonary MechanicsPulmonary PhysiologyRespiratory DiseaseRespiratory PathophysiologyRespiratory PhysiologyAirway-hemodynamics InteractionArterial Blood Gas AssessmentInspiratory MechanicsLeft-to-right Shunt QuantificationMechanical Ventilation In ChildrenPulmonary Gas ExchangePulmonary Gas TransferRight-to-left Shunt Assessment
The effect of altering peak airway pressure, respiratory frequency, and inspiration: expiration ratio on arterial blood gas tensions, blood pressure, and calculated right-to-left shunt was investigated in 6 infants undergoing mechanical ventilation for hyaline membrane disease with a Bennet ventilator. The use of a very long inspiratory phase resulted in a large increase in P<sub>a</sub>o<sub>2</sub> and fall in right-to-left shunt without affecting mean arterial blood pressure.
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