Endocrinology · 1946 · 100 citations · 0 references
Life SciencesBiochemistryEndocrinologyHormone BiochemistryNeuroendocrinologySteroid BiochemistryAdrenal EndocrinologyAdrenal HormonesAdrenal SteroidogenesisCholesterol MetabolismMammalian EndocrinologySteroid BiosynthesisAdrenal Cortex FunctionAdrenal Cortex PhysiologyAdrenal Cortex SteroidogenesisAdrenal Cortical HormonesAdrenal Steroid BiosynthesisAdrenal Steroid MetabolismAdrenal Steroid SynthesisAscorbic Acid Physiology
IT HAS ALREADY been reported that in the rat the adrenal cholesterol, a possible precursor of the adrenal cortical steroids, is lowered following administration of pituitary adrenotrophic hormone (Sayers, Sayers, Fry, White and Long, 1944). Preliminary studies (Sayers, Sayers, Lewis and Long, 1944) have indicated that the ascorbic acid content of this gland is also depleted by adrenotrophic hormone. This paper is a more complete report of these effects in the rat and extends the observations to the guinea pig, an animal which cannot synthesize ascorbic acid.