Archives of Dermatology and Syphilology · 1938 · 12 citations · 1 references
MedicineDermatologyPharmacotherapyImmunopathologyInfectious Disease PathologyParasitic Skin DiseaseInfectious DermatosesTreatmentSkin Disease Remedies
Germanin was introduced in 1928 by Kleine1for the treatment of trypanosomiasis, in which it has been somewhat effective. Veiel2in 1931 first suggested the use of germanin in the treatment of pemphigus, reporting 3 cures among 4 cases. Fabian3in 1933 reported the clinical cure of pemphigus in a boy 4 years old after four injections of germanin, after other measures had been ineffective. An elderly woman with diabetes and pemphigus was treated with this drug by Fabian; a high fever developed, and the patient died after the third injection. In the same year Zoon4reported the use of germanin in a case of pemphigus; there was rapid healing of lesions, followed by a recurrence in six months which proved fatal in spite of further medication. Zoon gave germanin also to 6 patients afflicted with dermatitis herpetiformis. There were a favorable response in 5 cases
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