Science · 1962 · 48 citations · 8 references
Veterinary MedicineImmunologyInfectious DiseasesClinical ImmunologyDiagnostic ParasitologyParasite ImmunologyAntibody CharacterizationAntigen Detection AssaysBlood ParasitesMalariaProtozoan ImmunologySerological DiagnosticsMalaria ImmunologyMalaria ParasitesParasite Antibody DetectionParasite-specific AntibodiesPlasmodium VivaxSerological Testing For ImmunitySporozoite Antigens
No reliable serological test has been available in the past to follow the course of antibody production in malarial infections. The indirect method of immunofluorescence was utilized in this investigation to study antibody response to sporozoite-induced Plasmodium vivax infections in two human volunteers. Malarial antibody was demonstrated approximately 3 weeks after infection, and has persisted thus far for 121 days. These preliminary results suggest that this method of serological testing is specific and provides a sensitive means of titrating antibody produced in malarial infections.
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