Treatment of Sheep Steroid–Induced Ocular Hypertension with a Glucocorticoid-Inducible MMP1 Gene Therapy Virus

Abstract

A single dose of a gene therapy vector carrying an inducible metalloproteinase human gene can both protect against the IOP increase produced by corticosteroid instillation in the sheep model and quickly reverse the IOP increase previously elicited by the corticosteroid. These results are a first step toward a treatment of steroid-glaucoma with inducible overexpression of extracellular matrix modulator genes.