A 5‐Month Period of Epilepsy Impairs Spatial Memory, Decreases Anxiety, but Spares Object Recognition in the Lithium‐pilocarpine Model in Adult Rats

Abstract

In li-pilo rats having experienced SRS for 5 months, performance in the object-recognition task is spared, which suggests that object discrimination remains relatively intact despite extensive damage. Neuronal loss in regions mediating memory and anxiety, such as hippocampus, entorhinal cortex, and amygdala, may relate to impaired spatial orientation and decreased anxiety.