Induction of Antitumor Immunity by Interleukin-2 Gene-Transduced Mouse Mammary Tumor Cells Versus Transduced Mammary Stromal Fibroblasts

Abstract

Our studies caution against the use of IL-2 gene-transduced syngeneic stromal cells as an alternative strategy of gene therapy for cancer. However, they may allow study of the mechanisms of tumor antigen recognition and the possible involvement of co-stimulatory signals for effective tumor vaccination by gene-modified cells.