Newly formed E‐cadherin contacts do not activate Cdc42 or induce filopodia protrusion in human keratinocytes ¹

Abstract

We conclude that Cdc42 does not participate in the early events that initiate stable cadherin adhesion in keratinocytes. Yet, it is feasible that Cdc42 may be activated at later time points or by other receptors. Cdc42 can then participate in additional functions during polarization, such as Golgi re-positioning or basolateral trafficking.